Dr. Muhammad Afzal

  • M. Pharm, Ph. D
    Assistant Professor (Pharmacology & Pharmacotherapeutics)
    Office: Pharmacology Lab 2
    Phone: +91-7351662121
    Email: afzal@theglocaluniversity.in

    RESEARCH
    Research interests include Molecular mechanisms of neurodegenerative diseases & anti cancer drug development.

    EDUCATION

    Qualification

    Year

    University

    B. Pharm

    2007

    HNBGU (A central University), Srinagar, India

    M. Pharm

    2009

    SK Patel College of Pharm Edu. & Res., Gujrat, India

    Ph. D

    2014

    Pacific University, Udaipur, India 


    SCIENTIFIC EXPERTISE:
    • Well versed with the use of analytical instruments and techniques like UV, Biochemistry semi-auto analyzer, Fully automated Heamatoanalyzer, cooling centrifuge, Power lab & Biopac.

    • Expertise in Animal handling (Rat, Mouse, Rabbit, Guinea pig) - PO, IP, IM, SC and IV dosing, Blood collection from retro orbital plexus, tail vein, intracardiac and rabbit marginal ear vein. Recording of E.C.G and Blood Pressure measurements in rats. Isolated tissue experiments (Fundus, Ileum, Colon, Uterus, Anococcus, Tracheal chain, Thoracic aorta etc.) and in establishment of mechanism of action of drugs.

    • Familiar well with the application and usage of Langendroff’s assembly.

    • Adroit in various animal models like Asthma, Diabetes, Anti-convulsant, Analgesics and anti-inflammatory, Hypertension, Ulcer, Uroliathiasis, Inflammatory bowel disease, Renal ischemia reperfusion, Cardiovascular disease and cancers.

    • Appreciable understanding of the concepts related to Intellectual Property Management and Regulatory Affairs & applications of Biostatistics in health sciences.

    EXPERIENCES:
    • Working as an Assistant Professor of Pharmacology & Pharmacotherapeutics for last two years in Glocal School of Pharmacy, The Glocal University, Saharanpur.

    • Worked as an Assistant Professor of Pharmacology and dealt with the subjects like Pharmacology and Pharmacotherapeutics for 1 year in GRD Institute of Management and Technology, Dehradun.

    • Worked as Lecturer of Pharmacology for 8 months in Himalayan Institute of Pharmacy & Research, Dehradun.

    • Worked as visiting faculty for PG Pharmacology students in School of Pharmacy, Bharat Institute of Technology, Meerut, and dealt with the subjects like Basic Clinical Pharmacology and Therapeutics as well as Drug Screening Techniques

    • Expert in the handling of various animal species like rats, mice, rabbits, hamsters and guinea pigs etc.

    • Co-supervisor of 12 PG Pharmacology students for both preclinical and clinical studies in Uttarakhand Technical University, Dehradun, Uttarakhand, India.

    • Reviewer of Journals Expert opinion on Current Drug Delivery, Pharmaceutical Biology, Informa Health Care, International journal of pharmacy and pharmacology & Wudpecker journal of medical sciences, Phytotherapy research, Wiley Blackwell, International Journal of Medicine and Medical Sciences, Food function etc.

    • Worked as “Trainee” in SPEED LIFE SCIENCES INCL. At- Roorkee, Uttarakhand for 1 month

    • Evaluator and Question Paper Expert at UG level (Pharmacy) for Different Universities

    PRESENTATIONS/CONFERENCE/WORKSHOP PROCEEDINGS:
    • Oral presentation on “Combination therapy in diabetes (Synthetic and herbal medicine): A novel approach”, in an international conference NHPBMS/ORAL/ROLL NO. / 15.

    • Oral presentation on “Wound healing activity of ursolic acid stearoyl glucoside isolated from Lantana camara”, in an international conference NHPBMS/ORAL/ROLL NO. / 43.

    • Poster presentation on “Protective effect of Aminoguanidine in diabetes induced hyperalgesia”in 40th Indian Pharmacological Society and international conference on translational pharmacology, 2008, held at Delhi.

    • Participated as a delegate in national workshop on “Clinical research & Regulatory Affairs” held at K.B.Institute of Pharmaceutical Edu.& Research, Gandhinagar, 2008.

    • Participated at the International conference on cardiovascular disease held at surat,2008.

    • Participated as a delegate in 26th annual conference of Indian pharmacological society Gujarat Chapter at Vapi, Gujarat in 2008

    • Participated in the CPCSEA National Conference 2010 held at india habitate centre, New Delhi.

    RESEARCH OUTCOMES:
    PUBLICATIONS IN JOURNALS:

    S.No

    Title

    Type

    Journal

    Impact factor

    1

    Anti-inflammatory potential of a novel steroidal derivative from Bryophyllum pinnatum

    Research

    Fitoterapia, Elsevier, 83 (2012) 142–14

    2.2

    2

    Talc used in anticancer drugs is promoter for diabetes in hepatocellular carcinoma induced rats

    Research

    European Journal of Cancer, 2014; 50: 247-248

    5.2

    3

    Combination of sulfamethoxazole and selenium in anticancer therapy: a novel approach.

    Research

    Molelular & Cellular Biochemistry, 2013; 384(1-2): 279-285

    2.3

    4

    Anti-diabetic potential of ursolic acid stearoyl glucoside: A new triterpenic gycosidic ester from Lantana camara

    Research

    Fitoterapia, Elsevier, 2012; 83: 853–858

    2.2

    5

    Fixed dose combination therapy Loperamide and Niacin ameliorates diethylnitrosamine- induced liver carcinogenesis in albino Wistar rats

    Research

    RSC Advances, Royal Society of Chemistry, 2015; 5: 679-696

    3.8

    6

    Cancer initiating properties of erythrosine supplemented withsub necrotic dose of diethyl nitrosamine: potential effects onbiochemical parameters of liver, Vitamin C and E

    Research

    Molecular & Cellular Toxicology, 2015, 11:0-0

    1.2

    7

     

    Pharmacological Evaluation of Gatifloxacin in Chemically Induced Hepatocarcinogenesis: A New Tool for Hepatocellularcarcinoma Treatment

    Research

    Journal of Cancer Sciences & Research, OMICS, 2012; 5(1): 18-22

    5.2

    8

    Anticancer effect of rosiglitazone in rats treated with N-nitrosodiethylamine via inhibition of DNA synthesis: an implication for hepatocellular carcinoma

    Research

    RSC Adv., 2015: 5; 68385-68391

    3.8

    9

    Rutin Attenuate CarfilzomibInduced Cardiotoxicity Through Inhibition of NFκB, Hypertrophic Gene Expression and Oxidative Stress

    Research

    Cardiovascular Toxicology 2015 Dec 26.

    1.7

    10

    Therapeutic exploration of betulinic acid in chemically induced hypothyroidism

    Research

    Molelular & Cellular Biochemistry, 2014; 386(1-2): 27-34

    2.3

    11

    Anticonvulsant activity of ethanol extracts of Vetiveria zizanioides roots in experimental mice

    Research

    Pharmaceutical Biology, 2013 Dec;51(12):1521-4

    1.2

    12

    Hepatoprotective potential of new steroid against carbon tetrachloride-induced hepatic injury

    Research

    Molelular & Cellular Biochemistry, 2013; 378(1-2): 275-81

    2.3

    13

    Antineoplastic potential of Bryophyllum pinnatum lam. on chemically induced hepatocarcinogenesis in rats

    Research

    Pharmacognosy Research, 2013; 5(4): 247-53.

    1.3

    14

    Pharmacological evaluation of anxiolytic activity of ursolic acid stearoyl glucoside isolated from Lantana camara

    Research

    CNS Neuroscience & Therapeutics, Wiley, 2012; 18(8): 707-708.

    4.5

    15

    Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation

    Research

    CNS Neuroscience & Therapeutics, Wiley, 2012; 18(9): 799-800.

    4.5

    16

    Antiobesity potential of ursolic acid stearoyl glucoside by inhibiting pancreatic lipase

     

    Research

    European Journal of Pharmacology, Elsevier, 2013 709: 28-36

    2.7

    17

    Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats

    Research

    J Ethnopharmacol, Elsevier, 2012; 141: 810– 816

    3.7

    18

    Anxiolytic poential of ursolic acid derivative—a stearoyl glucoside isolated from Lantana camara L. (Verbanaceae)

    Research

    Asian Journal of Tropical Medicine, Elsevier, 2013: 433-437

    1.1

    19

    Antifungal effect of new combination of gatifloxacin in combination with copper ions

    Research

    The Journal of Antibiotics, 2014; 67: 499-504

    2.7

    20

    Anticancer effect of of ursolic acid stearoyl glucoside against N-diethylnitrosamine induced hepatocellular carcinoma in rats

    Research

    Journal of Physiology & Biochemistry, Springer, 2013; 69: 687695

    2.6

    21

    Antiulcer and antioxidant activity of new steroid from Morus alba

    Research

    Life Sciences, 2013: 92; 202–210

    2.7

    22

    Polypharmacy (herbal and synthetic drug combination)-A novel approach in treatment of type-2 diabetes and its complications in rats

    Research

    Journal of Natural Medicine, Springer, 2013; 67; 662-671

    1.7

    23

    Preventive effect of metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in rats

    Research

    Pharmaceutical Journal, Elsevier, 2012; 20: 365–370

    1.0

    24

    Evaluation of anxiolytic activity of embelin isolated from Embelia ribes

    Research

    Biomedicine & Aging Pathology, Elsevier, 2012; 2: 45-47

    --

    25

    Pharmacological, biochemical and toxicological evaluation of Potash Alum as anti-obesity agent

     

    Research

    International Journal of Pharmacy and Pharmaceutical Science, 2012; 4: 90-93

    0.38

    26

    Anti-obesity potential of potash alum: Pharmacological and Biochemical approach

     

    Research

    Pharmacologia, U.K., 2012; 3(12): 729-733

    --

    27

    Aphrodisiac properties of Polygonatum verticillatum leaf extract

    Research

    Asian Pacific Journal of Tropical Disease, Elsevier, 2012: S841-S845

    0.80

    28

    Pharmacological Role of Alstonia scholaris Leaves for its Anticonvulsant and SedativeAction

    Research

    American Journal of Phytomedicine and Clinical Therapeutics, 2013; 1: 478-490

    --

    29

    Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats.

    Research

    Pharmaceutical Biology, Informa Healthcare, 2013; 51: 856-862

    1.2

    30

    Anticonvulsant and depressant-like activity of ursolic acid stearoyl glucoside isolated from Lantana camara L. (verbanaceae

    Research

    Asian Pacific Journal of Tropical Disease, Elsevier, 2012: S453-S456

    0.73

    31

    Formulation and evaluation of sustained release matrix tablet of rabeprazole using wet granulation technique

    Research

    Journal of Pharmacy & Bioallied Sciences 2014; 6(3): 180-184

    --

    32

    Effect of Bryophyllum pinnatum Lam. on N-diethylnitrosamine induced hepatic injury in rats

    Research

    Pharmacologia, 2013; 4(2): 82-88

    --

    33

    Pharmacological and biochemical evaluation of potash alum as anti-obesity agent: A new tool for treatment of obesity

    Research

    Journal of Aging: Research and Clinical Practice, Germany Publisher, 2013: 32-34

    --

    34

    Antidiabetic potential of triterpenoid saponin isolated from Primula denticulate

    Research

    Pharmaceutical Biology, Informa Healthcare, 2014; 52: 750-755

    1.2

    35

    Anxiolytic effect of Oxalis corniculata (Oxalidaceae) in mice

    Research

    Asian Pacific Journal of Tropical Disease, Elsevier, 2012: S837-S840

    0.73

    36

    Anticonvulsant activity of Morus alba and its effect on brain gamma-aminobutyric acid level in rats

    Research

    Pharmacognosy Res. 2014 Apr-Jun; 6(2): 188–189.

    1.3

    37

    Advancement in multifunctional nanoparticles for the effective treatment of cancer

    Review

    Expert Opinion on Drug Delivery, Informa Health care, 2012; 9: 367-381

    4.9

    38

    Insight into the biomarkers as the novel anti-psoriatic drug discovery tool: A contemporary viewpoint

    Review

    Current Drug Discovery Technologies, BSP, 2012; 9: 48-62

    3.26

    39

    Biometals: New tools for treatment of obesity and its related metabolic disorders

    Review

    Journal of Aging: Research and Clinical Practice, Germany Publisher, 11 (2012) 1-3

    --

     

    40

    Classical to current approach for the treatment of psoriasis

    Review

    Journal of Endocrine Metabolic Disorder, BSP, 12(3): (2012 )287-302

    2.80

    41

    Omega-3 fatty acids as pharmacotherapeutics in psoriasis: current status and scope of nanomedicine in its effective delivery

    Review

    Curr Drug Targets, 2013;14(6): 708-22

    3.26

    42

    Ectopic pregnancy: a review

    Review

    Archives of Gynecology & Obstet, 2013; 288:747–757

    1.4

    43

    Emergence of nanomedicine as cancer targeted magic bullets: recent development and need to address the toxicity apprehension

    Review

    Current Drug Discovery Technologies, Bentham Scien 2012 Dec;9(4):319-29

    --

    44

    Bryophyllum pinnatum: A review

    Review

    International Journal of Research in Biological Sciences 2012; 2(4): 143-149

    --

    BOOKS:

    • Reference book on “Combination therapy (herbal and synthetic) in diabetes complications” (ISBN No: 978-3-8484-4750-3, 2012, Lambert publication, Germany).

    • Book on “Human, Physiology and Health Education” (ISBN No: 978-3-8484-4559-2, 2012; Lambert publication, Germany).

    • Reference book on “Characterization and Pharmacological evaluation of Lantana camara” (ISBN No: 978-3-8484-0483-4, 2012; Lambert publication, Germany).

    • Antiepileptic and antipsychotic activities ofOxalis corniculata Linn. (ISBN No: 978-3-8484-3946-1, 2012; Lambert publication, Germany).

    PATENT

    • Patent on “Extraction and isolation of novel cardioprotective ursolic acid stearoyl glucoside from the leaves of Lantana camara Linn.” Official Journals of the Patent Office, Application No.273/DEL/2013 A, Isssue no. 34/2014, Page no. 32197.